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. Author manuscript; available in PMC: 2024 Feb 15.
Published in final edited form as: Neuron. 2022 Dec 22;111(4):526–538.e4. doi: 10.1016/j.neuron.2022.11.015

Figure 7. PCO causes a pain-related reduction in voluntary movement which is partially prevented by genetic ablation of Piezo2 function.

Figure 7.

(A). Schematic representation of PCO procedure and open field recording. (B). Representative images illustrating heat maps of voluntary movements of sham- and PCO-treated wild type C57BL/6J mice. (C-E). PCO procedure markedly reduced total moving distance (C), and total time spent moving (D), but increased total time spent stationary (E). ***P<0.001, ****P<0.0001, two-way ANOVA, n=6 mice per group. (F). Representative images illustrating heat maps of voluntary movements in Piezo2fl/fl (left) and Trpv1Cre::Piezo2fl/fl (right) mice after PCO surgery in open field test. (G-I). Trpv1Cre::Piezo2fl/fl mice showed increased total moving distance (G) and time spent moving (H) and decreased time spent stationary (I) compared with Piezo2fl/fl mice. *P<0.05, two-way ANOVA, n=6 mice per group. All data are expressed as mean ± S.E.