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. Author manuscript; available in PMC: 2024 Feb 17.
Published in final edited form as: J Org Chem. 2023 Feb 6;88(4):2089–2094. doi: 10.1021/acs.joc.2c02420

Scheme 3. Substrate scope of copper-mediated deboro-bromination.

Scheme 3.

aReactions were performed with 7.5 MBq [77Br]bromide, 1 μmol of boronic pinacol ester precursor, 0.5 μmol of [Cu(py)4(OTf)2], and 3,4,7,8-Tetramethyl-1,10-phenanthroline (Ligand) stirred in 100 μL of 9:1 MeOH::H2O for 30 minutes at room temperature (rt). bAll reactions were conducted in duplicate and RCC calculated as activity trapped on C18 cartridge versus starting activity scaled by HPLC radioactivity detector chromatogram product peak area versus all peak areas to account for impurities.