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. Author manuscript; available in PMC: 2024 Feb 17.
Published in final edited form as: J Org Chem. 2023 Feb 6;88(4):2089–2094. doi: 10.1021/acs.joc.2c02420

Scheme 4. Radiobrominated biological targeting vectors.

Scheme 4.

Reactions were performed on a 7.5 - 400 MBq scale with 1 μmol of boronic pinacol ester precursor, 0.5 μmol of [Cu(py)4(OTf)2] and 3,4,7,8-Tetramethyl-1,10-phenanthroline stirred in 100 μL of 9:1 MeOH::H2O for 30 minutes at room temperature. RCC’s were calculated by activity trapped on C18 vs starting activity scaled by HPLC chromaogram radioactivity peak integration to account for impurities. RCY was calculated based on activity isolated from preperatory HPLC versus starting activtiy of the reaction.