Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 8;78(3):297–308. doi: 10.1136/thorax-2022-219103

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Differential microbial pathways between lymphotypes showing similar core pathways enriched in the Mycobacterium-dominated lymphotype. (A) Volcano plot showing differentially abundant microbial pathways inferred by PICRUSt2 in oL2 vs oL4 representing pathways enriched in oL4 compared with every other oL in all patients (overall including dTBLs and nTBLs). Significantly more discriminatory pathways appear closer to the left or right, and higher above the threshold (red dotted line, FDR=0.05) as significance increases. Relative pathway abundance is indicated by circle size. (B) 65.5% of all inferred pathways enriched in oL4 compared with each other oLS were common, while (C) 85.8% were common in dL3 compared with each other dTBL lymphotypes. Differentially enriched pathways common in all comparisons with the Mycobacterium dominant lymphotype included pathways involving lipid biosynthesis, fatty acids and SCFA metabolism, that is, lipid biosynthesis proteins, propanoate metabolism, benzoate degradation, and valine, leucine and isoleucine degradation. dL, dTBL lymphotype; dTBLs: definite-TBLs; FDR, false discovery rate; nTBLs: non-TBL; oL: overall lymphotype; SCFA: short-chain fatty acid.