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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Neurobiol Aging. 2022 Dec 21;124:39–50. doi: 10.1016/j.neurobiolaging.2022.06.014

Figure 7.

Figure 7.

Quantification of soluble tau by ELISA. AAV9 tauP301L and tauwild-type exhibit early and late phosphorylated soluble fraction markers of tauopathy. (A) The total tau concentration measured by ELISA assays on the detergent soluble hippocampal fraction normalized to total protein. (B) The Ser199 concentration measured by ELISA assays on the detergent insoluble hippocampal fraction normalized to total protein. (C) Quantification of the positive fractional area of histological phospho-tau Ser396. (D) The oligomeric tau concentration measured by ELISA assays on the detergent soluble hippocampal fraction normalized to total protein. Data are presented as mean ±SEM (error bars). Each symbol represents one mouse. * p<0.05, ** p<0.01, *** p <0.001 Tukey’s post-hoc analyses.