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. 2022 Sep 13;44(3):670–679. doi: 10.1038/s41401-022-00984-6

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 3 — a Enrichment of the lipid synthesis pathway and its leading-edge genes. Top 6 upregulated pathways in U87R according to the FDR values by GSEA analysis on gene expressions related to lipid synthesis in U87 and U87R cells (upper). Enrichment plot from GSEA analysis for the “Regulation of Cholesterol Biosynthesis by SREBP” pathway from the microarray data (left). GSEA-derived heat maps of leading-edge genes in the red box on the left (right). b Protein level of lipid-related pathway in U87 and U87R cells. Beta-actin (β-Actin) was used as a loading control. Relative quantitation of SREBP1 (c) and SREBP2 (d) levels normalized to β-Actin from b (n = 3). Statistics are as in Fig. 2.