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. 2023 Feb 24;14(2):157. doi: 10.1038/s41419-023-05684-5

Fig. 1. MXRA5 is overexpressed in pancreatic cancer.

Fig. 1

TCGA-GTEx-PAAD cohorts show the relative MXRA5 mRNA transcripts in 179 cases of pancreatic ductal adenocarcinoma (PDAC) tissues (“Tumor”) and 171 cases of normal pancreatic tissues (“Normal”) (A); GEO dataset (GSE28735) showed that the number of MRXA5 transcripts in 45 PDAC tissues and matched adjacent paracancer tissues (B). GEO dataset (GSE62452) showed the number of MRXA5 transcripts in the normal pancreatic tissues (“Normal”) and in pancreatic cancer tissues with different clinical-pathological stage (C). The Kaplan Meier Survival curve of MXRA5-low (blue) and MXRA5-high (red) pancreatic cancer patients was presented (D). Subgroup analyses, based on the different clinical features of the pancreatic cancer patients, were performed as well (E–G). The representative MXRA5 IHC images of six PDAC patients (“Patient 1#” and “Patient 6#”) were presented (H). MXRA5 mRNA and protein expression in pancreatic cancer tissues (“Ca”) and THE matched paracancer tissues (“ParaCa”) of sixteen (n = 16) different PDAC primary patients was shown (I and J). MXRA5 mRNA and protein expression in the listed pancreatic cancer cells and primary human pancreatic ductal epithelial cells (“pEpi”) was tested (K and L). “TPM” stands for transcripts per million. “TRP” stands for “true positive rate”. “FRP” stands for “false positive rate” *P < 0.05, **P < 0.01, ***P < 0.01. Scale bar = 100 μm.