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. 2023 Feb 24;14:1055. doi: 10.1038/s41467-023-36691-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a A schematic diagram of the stepwise progression of HNSCC. b Cell types of the 54,239 cells are indicated in a UMAP plot. c Distribution of tissue types, HPV infection status, and individual patients are shown. d Cell compositions of the major cell types of epithelial cells (n = 6106), fibroblasts (n = 12,336), NK/T cells (n = 17,869), and B/Plasma cells (n = 7,437) are shown according to the tissue types and patients’ HPV infection status. Data points represent the average value of the cell type proportions in each sample. Box plots show the median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). Source data are provided in a Source Data file.