FIG. 1.

The CELF family members are closely related. (A) All of the CELF proteins possess the same domain structure: three RRMs and a divergent domain of unknown function between RRM2 and RRM3. Nomenclature is designed to consider CUG-BP and ETR-3 as CELF1 and CELF2, respectively. (B) Sequences of five human CELF proteins derived from PCR-amplified cDNAs (see Materials and Methods). Blue, conserved nonpolar amino acids; red, conserved uncharged polar residues; green, conserved positively charged residues; gold, conserved negatively charged residues; black, nonconserved residues. Known alternatively spliced regions are shaded. Italic's, a region of allelic variation in CELF3 due to a variable number of CAG repeats. (C) Phylogenetic relationship of human CELF proteins.