Skip to main content
. 2023 Feb 24;14(2):156. doi: 10.1038/s41419-023-05689-0

Fig. 7. Depleting CD11c+ microglia in the late phase of stroke exacerbated WMI.

Fig. 7

A Representative DTI axial views of mice with rAAV-control and rAAV-taCasp3 injection. Quantification of FA value as the ratio of ipsilateral values to the contralateral values. n = 9 per group. B Immunofluorescence staining of SMI32 (red) and MBP (green) in the cortex and the striatum area of mice with rAAV-control and rAAV-taCasp3 injections. Scale bars, 100 μm. The ratios of SMI32 to MBP staining intensity in the injured cortex (C) and striatum (D). n = 5 per group. E Immunofluorescence staining of EdU (green) and APC (red) on the striatum area of mice with rAAV-control and rAAV-taCasp3 injections. The number of EdU single-positive cells, EdU and APC double-positive cells. n = 5 per group. Scale bars, 100 μm. F Immunofluorescence staining of EdU (green) and Pdgfrα (red) on the striatum area of mice with rAAV-control and rAAV-taCasp3 injections; EdU and Pdgfrα double-positive cells per field. n = 5 per group. Scale bars, 100 μm. G The percentage of EdU+ APC+ and EdU+Pdgfrα+ cells in EdU-positive cells. n = 8 per group. *p < 0.05, **p < 0.01, ***p < 0.001 compared to rAAV-control group, and ns not significant. Values were mean ± SEM.