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Size, encapsulation efficiency, and drug to lipid ratio of the optimized, folate conjugated, lead liposome candidate, NIRB-DOX-FA. Nanoparticle size was determined by DLS. NIRB and DOX concentrations were determined by HPLC–UV analysis and lipid quantification was performed by HPLC-ELSD.
| Size (nm) | Encapsulation efficiency (%) | Drug:lipid molar ratio | Resultant NIRB:DOX molar ratio | |
|---|---|---|---|---|
| NIRB | DOX | |||
| 124.6 ± 53.9 | 87.6 ± 19.9 | 71.5 ± 17.3 | 0.4 ± 0.1 | 9.4 ± 0.6:1 |
