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. 2023 Feb 24;14:1061. doi: 10.1038/s41467-023-36620-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Percentage of significantly created and destroyed regions derived from PAD2- and PAD4-citrullinated antigens that contain citrulline residues. b Frequency of citrulline residues in each position (P4-P4’) of citrulline-containing cleavage sites enriched in the citrullinated antigens. P values were calculated via bootstrapping to compare the observed frequency of citrullines to the expected frequency of citrullines in each position. Only significant P values (≤0.05) are shown. c Violin plots depicting the actual minus expected distance from each significantly changed region to the nearest citrulline residue in the linear amino acid sequence. d Arginine frequency shown for all autoantigens used in this study. The horizontal dotted line represents the average vertebrate protein arginine content. e Antigen processing change score versus % arginine content (frequency) for each PAD2- or PAD4-citrullinated (cit) antigen.