Fig. 1.

a, b show vitamin B₆, B₁₂ and folate interacting protein networks in humans and mice. Results showing top ten pathways enriched for vitamin B₆, B₁₂ and folate interacting protein in c human and d mice. Network showing deregulated pathway in HD and overlapping of pathway genes associated with vitamin B₆, B₁₂ and folate as cofactors in following datasets. e Human peripheral blood-HPB [GSE1751], f Human ventral head of caudate nucleus-HVHCN [GSE26927] and g mice brain hemisphere-MBH [GSE3621] datasets. h Vitamin B₆, B₁₂ and folate interacting genes and their expression in HD patients and mice model of HD. The networks a, b, e, f and g were generated in Cytoscape 3.8.2. The plots c, d were made in Origin software