Table 4.

Outcomes of the cardiac/muscular irAEs according to time of onset (within two cycles or after two cycles), clinical manifestation (only myositis, only myocarditis, or both), and instrumental findings

	N	Complete remission, n	Partial remission, n	Neither improvement nor death, n	Death, n	Not reported, n
≤2 cycles	96	30	9	2	48	7
>2 cycles	36	17	11	2	3	3
Only myositis	46	21	8	1	10	6
Only myocarditis	49	18	10	0	21	0
Both myositis and myocarditis	43	11	3	3	22	4
LVEF ≤45%	22a	6	6	1	9	0
LVEF> 45%	54a	20	9	2	22	1
Arrhythmia at ECG	47b	11	6	2	27	1
No arrhythmia at ECG	37b	16	8	1	10	2
Ischemic signs at ECG	19b	8	2	0	9	0
No ischemic signs at ECG	65b	19	9	3	27	7

ECG, electrocardiogram; irAEs, immune-related adverse events; LVEF, left ventricular ejection fraction.

^aOnly 76 patients had data on echocardiographic assessment of LVEF.

^bOnly 84 patients had data on ECG.