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. 2023 Feb 25;22:39. doi: 10.1186/s12934-023-02043-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a Immunization analysis of mice injected with HBc VLP-E vaccine, HBc VLP, and PBS controls. The total specific SARS-CoV-2 spike IgG production presented in RU/ml two and 4 weeks after the second dose injection. Each measure is presented as the mean ± SD value of three mice with two replicates and analyzed by Duncan's test (p < 0.01). b Comparison of the specific IgG production between the two intervals after the HBc-VLP E immunization in both conditions with and without adjuvant. Each measure is presented as the mean ± SD value of three mice analyzed by Duncan’s test (p < 0.01). c Comparison of the specific IgG production with and without adjuvant utilization after four weeks of HBc-VLP E injection. Each measure is presented as the mean ± SD value of three mice with two replicates and analyzed by Duncan's test (p < 0.01)