Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 25;14(2):159. doi: 10.1038/s41419-023-05696-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A, B GSEA of TCGA-PRAD shows NRP1 is positively related to the EGFR pathway. C, D Immunoblot assay elucidates that NRP1 depletion attenuates EGFR phosphorylation level, while ectopic overexpression of NRP1 promotes EGFR phosphorylation level. E, F IHC assay and the correlation analysis represent that NRP1 protein is positively correlated with the expression of phosphorylated EGFR protein in PCa tissues (scale bar = 400 μm). G NRP1 (green) and EGFR (red) co-localization is examined by the immunofluorescence assay (scale bar = 15 μm) and the nucleus is indicated by DAPI (blue) staining. H Exogenous Co-IP assay represents NRP1 could interact with EGFR in 293T cells. I, J Endogenous Co-IP assay proves NRP1 could interact with EGFR in PC-3 and DU-145 cells. Statistical significance was assessed using a two-tailed t test.