Skip to main content
. 2023 Feb 25;14(2):159. doi: 10.1038/s41419-023-05696-1

Fig. 8. NRP1 inhibitor EG01377 attenuates PCa proliferation and migration via EGFR/AKT signaling axis.

Fig. 8

A–C Clone formation assay, D–F transwell assay, and G, H MTT assay represent that NRP1 inhibitor EG01377 attenuates clone formation, proliferation, and migration ability in a concentration-dependent manner. I Immunoblot results elucidate that EG01377 attenuates AKT, GSK3β, and mTOR phosphorylation levels in a concentration-dependent manner. J A schematic model of HIF1α-NRP1-EGFR/AKT signaling axis promoting prostate cancer progression. Statistical significance was assessed using a two-tailed t test. Error bars represent the standard deviations of three independent experiments. **P < 0.001.