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. 2023 Feb 25;21:152. doi: 10.1186/s12967-023-03996-w

Fig. 5.

Fig. 5

Clustering analysis of SARS-CoV-2 proteins. Heat map and dendrogram illustration of SARS-CoV-2 proteins based on the frequency of mutations in ten different regions of SARS-CoV-2 genomes. A Spike. B Envelope. C Membrane, D Nucleocapsid and E NSP12. NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide; HR, heptapeptide repeat sequence; TM, transmembrane; CT, cytoplasmic tail. LKR, serine-arginine (SR) rich-linker region; RBM, receptor binding motif; CP, cytoplasm domain; TMD α-helical transmembrane domain