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. 2023 Feb 2;26(3):106108. doi: 10.1016/j.isci.2023.106108

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Mechanistic and agnostic k-TSPs signatures for predicting the response to neoadjuvant chemotherapy in patients with triple-negative breast cancer

(A) Bar plot showing the frequency of the top 100 agnostic (red) and mechanistic (blue) scoring pairs across the different bootstraps.

(B) The top 10 most frequent agnostic (red) and mechanistic (blue) pairs sort by their frequency.

(C and D) Networks of the top 100 agnostic (C) and mechanistic (D) top-scoring pairs. Each pair consists of a gene voting for RD (red) and pCR (yellow). The vertex size corresponds to 2∗log2 of the individual gene frequency across unique pairs while the edge thickness corresponds to the log2 of the top scoring pair frequency.