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. 2023 Feb 2;26(3):106119. doi: 10.1016/j.isci.2023.106119

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Candidate SVs of high-altitude adaptation

(A) QTL enrichment analysis of Tibetan-specific SVs (TPSSVs).

(B) Significantly enriched QTLs for blood parameters.

(C) KEGG pathway enrichment analysis of 2,508 genes located within 5 kb upstream or downstream of the TPSSVs.

(D) Overlap among three gene sets. TPSSVGs refer to Tibetan-specific SV-associated genes, pHAAGs are candidate genes for high-altitude adaptation reported in the literature, and DEGs are the differentially expressed genes identified by Tang.

(E) Manhattan plot of the Fst statistics (Tibetan versus low-altitude pigs) of 3,141 SVs for TPSSVs in the NGS population supported by at least one sample. The dotted line indicates the threshold defining the top 5% (Vst = 0.299).