Table 3.
Individual thresholds for food allergens at oral food challenges performed before and immediately after the IgE immuno-adsorption.
Patient 1 |
Patient 2 |
Patient 3 |
Patient 4 |
Patient 5 |
||||||
---|---|---|---|---|---|---|---|---|---|---|
pre-IA | post-IA | pre-IA | post-IA | pre-IA | post-IA | pre-IA | post-IA | pre-IA | post-IA | |
OFC food 1 |
||||||||||
Food |
Baked egg | Baked egg | Baked milk | Lentil | Wheat | |||||
NOAEL - single dose (mg) | 2.088 | 584.64 | 20.88 | 584.64 | 260 | 390 | 58.65 | 4685.1 | 4050 | 6750 |
LOAEL - single dose (mg) | 6.264 | NA | 62.64 | NA | 390 | NA | 175.95 | NA | 6750 | NA |
NOAEL - cumulative dose (mg) | 2.088 | 1114.99 | 29.232 | 1114.99 | 447.2 | 837.2 | 82.11 | 7289.16 | 6311.25 | 13061.3 |
LOAEL - cumulative dose (mg) |
8.352 |
NA |
91.872 |
NA |
837.2 |
NA |
258.06 |
NA |
13061.3 |
NA |
OFC food 2 |
||||||||||
Food |
Baked milk | Baked milk | Hazelnut | Hazelnut | Baked milk | |||||
NOAEL - single dose (mg) | 1.3 | 130 | 0 | 39 | 69 | 2070 | 13.8 | 2070 | 0 | 390 |
LOAEL - single dose (mg) | 3.9 | 260 | 1.3 | 130 | 138 | NA | 69 | NA | 1.3 | NA |
NOAEL - cumulative dose (mg) | 1.3 | 187.2 | 0 | 57.2 | 82.8 | 4222.8 | 13.8 | 4222.8 | 0 | 837.2 |
LOAEL - cumulative dose (mg) | 5.2 | 447.2 | 1.3 | 187.2 | 220.8 | NA | 82.8 | NA | 1.3 | NA |
List of abbreviations: IA, IgE-immunoapheresis; LOAEL, Lowest Observed Adverse Effect Levels; NA, Not Applicable; NOAEL, No Observed Adverse Effect Level