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. 2023 Feb 8;26(3):106156. doi: 10.1016/j.isci.2023.106156

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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High throughput screening for compounds that enhance oligodendrocyte differentiation

(A and B) Scatterplot of the HTS for compounds that increase activity of MBP-driven secNLuc in the culture media. Plot represents fold change of secNLuc activity versus the compound ID for (A) LOPAC and (B) TOCRIS library of small molecules.

(C) A total of 240 compounds with some effect to increase MBP-NanoLuc expression are graphed as a pie-chart according to a class they fall on. The numbers indicate the number of molecules that fall on that class.