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. 2023 Feb 8;26(3):106156. doi: 10.1016/j.isci.2023.106156

Figure 6.

Figure 6

Ro1138412 and SR2211 promote differentiation of rodent OPCs

OPCs from P7-8 mice were purified using Anti-O4 microbeads and MACS purification method, and the purified OPCs were treated with one of the following molecules: Ro1138412, SR2211, T3 as positive control or DMSO.

(A) Immunostaining for MBP protein shows significant increase in MBP positive cells and MBP+ area in the drug treated samples.

(B–D) Quantification of MBP+ area (B) OLIG2+ cell number (C), and the MBP+ area relative to OLIG2+ cells in Ro1138412 treatment (top panels) and SR2211 treatment (bottom panels) compared to T3 and DMSO treatments. Data presented as mean ± SEM.