Table 1.

Major advantages and disadvantages of basic natural polysaccharides used in stimuli responsive wound healing applications.

Natural Polysaccharides	Advantages	Disadvantages
Chitosan/chitin	Facile modification methods, Versatility of functionalization, Inherent antibacterial activity, low cost	Performances of different batches greatly vary Non-soluble at neutral conditions Non-FDA approved Weak mechanical properties
Hyaluronic acid	Biocompatible, biodegradable, FDA-approved Inherent antioxidative properties Facile modification methods Versatility of functionalization High water-holding capacity	Weak mechanical properties Poor tissue-adhesion Fast degradation rates Expensive
Dextran	Biocompatible, biodegradable, FDA-approved Resistance to protein adsorption Facile modification methods Versatility of functionalization High water holding/absorbing capacity Low cost	Weak mechanical properties Poor tissue adhesion
Sodium alginate	Biocompatible, water-soluble Facile modification methods Low cost	Weak mechanical properties
Cellulose	Good biocompatibility, non-toxic, good mechanical properties	Solubility issues Non-adherent