Table 3.
Important residues for mammalian transmission, virulence, and resistance that are present in the Bat/UPE556/RSA/2018 viral protein sequences.
| IAV Proteins | Importance | Residues Present | References |
|---|---|---|---|
| PB2 | Mammalian transmission and virulence | S199, V504, N701 | [63,64,65] |
| PA | Mammalian transmission and virulence | N55, Y241, S404, V127, L550, L672 | [64,66] |
| PA-X | Enhanced host shutoff | P28, S65, K195, K198, K202, K206, and the 233–252 end of the PA-X protein | [67,68,69] |
| Increased virulence | R195K | [70] | |
| NP | Early adaptation markers for Mx-protein antiviral resistance | K305, K351 | [71] |
| M2 | Increased virulence | P69 | [72] |