Table 1.
Contemporary GRPR-targeted nanosystems for cancer therapy.
| Nanocarrier | Target Condition | Drug/Therapeutic Means | Reference |
|---|---|---|---|
| liposomes | prostate cancer, colon cancer, hepatic cancer |
Albendazole | [78] |
| lung cancer | - | [59] | |
| prostate cancer | Doxorubicin (DOX) | [39] | |
| phospholipid micelles | prostate cancer | Au(III)-dithiocarbamate complex (AuL12) | [38] |
| polymeric micelles | glioma | Coumarin-6 Camptothecin (CPT) |
[65] |
| prostate cancer | Monomethyl auristatin F (MMAF) | [69] | |
| elastin-like micelles | prostate cancer | - | [67] |
| Docetaxel (DTX) | [79] | ||
| nanostructured lipid carriers | lung cancer | Doxorubicin (DOX) | [21] |
| solid lipid nanoparticles | breast cancer | Doxorubicin (DOX) | [63] |
| PLGA nanoparticles | breast cancer | Docetaxel (DTX) | [18] |
| prostate cancer | Docetaxel (DTX) | [80] | |
| gold nanoparticles | cervical cancer | RAF peptide analog (Ac-Cys-Ahx-RAF) | [73] |
| prostate cancer | 99mTc | [27] | |
| 99mTc, 177Lu | [34] | ||
| - | [81] | ||
| Gallic acid (GA) | [51] | ||
| prostate cancer, colon cancer | 68Ga | [28] | |
| gold nanorods | breast cancer | Photothermal therapy—use of near-infrared laser irradiation | [48] |
| prostate cancer | Heat-labile cytotoxic free radical donor—AIPH | [82] | |
| graphene oxide | glioblastoma | Magnetic targeting, doxorubicin (DOX), near-infrared laser irradiation | [62] |