Figure 1.
Schematic diagram of the TGEV genome structure. Non-structural proteins, including ORF1a and 1b, ORF3a/3b and ORF7; structural proteins, including spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins. S protein is used to divide different TGEV subtypes: (a) nt1123–1128 deletion of the S protein is considered to be Purdue strain; (b) ORF3 nt−75–−60 and nt195–223 deletions (between S protein and ORF 3) are considered to be Miller subtypes; (c) and TGEV with a deletion of nt621–681 in S protein is variant strain PRCV and infects the porcine respiratory tract.