Table 3.
Comparing patients with and without disparity.
| Characteristics and Outcomes | Non-Disparity | Disparity * | p-Value |
|---|---|---|---|
| (n = 46) | (n = 66) | ||
| N (%) | N (%) | ||
| Age (years), median (range) | 46 (14–67) | 60 (17–77) | <0.0001 |
| Sex, male | 27 (59) | 43 (65) | 0.49 |
| Underlying disease | 0.09 | ||
| AML | 11 (24) | 26 (39) | |
| Others | 35 (76) | 40 (61) | |
| SCT—Allogeneic | 9 (20) | 19/65 (29) | 0.25 |
| GVHD | 7/44 (16) | 5/59 (8) | 0.24 |
| Neutropenia at the onset of IFI | 13/45 (29) | 29 (44) | 0.11 |
| Recovery from neutropenia during infection | 12/13 (92) | 25/28 (89) | >0.99 |
| Cumulative steroids ≥ 600 mg (prednisone equivalent) during infection | 22/45 (49) | 27/65 (42) | 0.45 |
| ICU at baseline | 8 (17) | 9/63 (14) | 0.66 |
| Diagnosis of IFI | |||
| Definite | 12/41 (29) | 17/62 (27) | |
| Probable | 22/41 (54) | 29/62 (47) | |
| Possible | 7/41 (17) | 16/62 (26) | |
| Organism of IFI | |||
| Aspergillus | 36 (78) | 52 (79) | 0.95 |
| Fusarium | 2 (4) | 7 (11) | 0.30 |
| Mucor | 2 (4) | 5 (8) | 0.70 |
| Trichosporon spp. | 2 (4) | 1 (2) | 0.57 |
| Others | 4 (9) | 1 (2) | |
| Invasive pulmonary infection or sinus infection | 27 (59) | 39/64 (61) | 0.81 |
| Primary therapy | 0.32 | ||
| Isavuconazole | 12 (26) | 22 (33) | |
| Voriconazole | 18 (39) | 17 (26) | |
| Amphotericin B | 16 (35) | 27 (41) | |
| Favorable response to primary therapy | |||
| At week 6 | 31/38 (82) | 48/55 (87) | 0.45 |
| At week 12 | 28/32 (88) | 44/50 (88) | >0.99 |
| At end of primary therapy | 30/39 (77) | 47/59 (80) | 0.75 |
| Adverse events related to primary therapy drug | 10 (22) | 13 (20) | 0.79 |
| Mortality since IFI diagnosis | |||
| All-cause death at week 6 | 3/45 (7) | 7/65 (11) | 0.52 |
| IFI-attributable death at week 6 | 3/45 (7) | 5/65 (8) | >0.99 |
| All-cause death at week 12 | 6/45 (13) | 11/65 (17) | 0.61 |
| IFI-attributable death at week 12 | 5/45 (11) | 8/65 (12) | 0.85 |
Note * A patient with disparity had to have at least one of the following features: age ≥ 65 years, obesity (BMI ≥ 30), diabetes mellitus, renal insufficiency or prolonged QT interval. For any variable with data missing or data non-applicable, the number of patients with data available for this variable was added as the denominator.