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. 2023 Feb 10;11(1):33. doi: 10.3390/pharmacy11010033

Table 5.

Toxic effects and doses of several compounds found in EOs.

Toxic Compound Effect Toxic Dose Reference
Pulegone hepatotoxic
irritant
carcinogenic
>460 mg/bw/day [9,24]
Methyl eugenol carcinogenic
genotoxic
>37 mg/kg bw/day [9,67]
Eugenol genotoxic
allergic contact dermatitis
asthma
rhinitis
>35 mg/kg bw [8,9,67]
Camphor gastrointestinal disorders
neurotoxic
seizures
>30 mg/kg bw [9]
Thujone neurotoxic >25 mg/kg bw [9,58]
Limonene irritant
carcinogenic
nephrotoxic
>500 mg/kg bw/day [38,50,58,90]
Linalool ataxia
narcosis
>2.79 g/kg/day [58]
Terpinene mutagenic >3.65 g/kg/day [58]
Pinene irritant >5 g/kg/day [58]