Table 1.
Pharmacokinetic parameters of human IgG following IV delivery of 0.5 g/kg to obese (OP) and lean (OP) rats.
| Parameter | Lean | Obese | ||
|---|---|---|---|---|
| Mean | SD | Mean | SD | |
| T1/2, day | 18.8 | 2.1 | 6.0 # | 1.6 |
| Cmax, mg/mL | 10.1 | 4.1 | 16.5 $ | 1.9 |
| AUC, day·mg/mL | 68.8 | 11.3 | 41.0 # | 6.5 |
| Vss, mL/kg | 173.9 | 45.9 | 77.6 # | 6.4 |
| CL, mL/day/kg | 7.5 | 1.6 | 12.4 # | 1.8 |
AUC—area under the serum concentration-time curve extrapolated to infinity; T1/2—terminal half-life; Cmax—maximal serum concentration (measured immediately after the end of infusion); Vss—volume of distribution at steady state; CL—systemic clearance. $—statistically different from lean group (p < 0.01). #—statistically different from lean group (p < 0.001).