Table 5.
Pearson’s correlation coefficient (95% confidence interval) between available IgG pharmacokinetic parameters and select descriptors of body composition in humans.
| Body Mass Index | |||||
|---|---|---|---|---|---|
| Parameter | IgGTotal | IgG1 | IgG2 | IgG3 | IgG4 |
| T1/2 | −0.59 (−0.92, 0.19) | −0.55 (−0.25, 0.91) | −0.57 (−0.91, 0.22) | −0.77 * (−0.96, −0.15) | −0.50 (−0.89, 0.32) |
| [Cmax] | 0.22 (−0.58, 0.80) | 0.23 (−0.57, 0.80) | 0.28 (−0.53, 0.82) | −0.07 (−0.71, 0.70) | 0.22 (−0.57, 0.80) |
| [Cmin] | −0.36 (−0.46, 0.85) | −0.32 (−0.83, 0.50) | −0.37 (−0.45, 0.85) | −0.53 (−0.90, 0.27) | −0.29 (−0.52, 0.82) |
| [Δ] | 0.75 * (0.09, 0.95) | 0.72 * (0.03, 0.95) | 0.55 (−0.25, 0.91) | 0.49 (−0.33, 0.89) | 0.41 (−0.42, 0.87) |
| Body fat mass | |||||
| T1/2 | −0.54 (−0.90, 0.27) | −0.50 (−0.31, 0.89) | −0.48 (−0.88, 0.34) | −0.73 * (−0.95, −0.05) | −0.42 (−0.87, 0.40) |
| [Cmax] | 0.29 (−0.52, 0.83) | 0.30 (−0.51, 0.83) | 0.34 (−0.48, 0.84) | −0.05 (−0.68, 0.73) | 0.29 (−0.52, 0.83) |
| [Cmin] | −0.28 (−0.53, 0.82) | −0.23 (−0.57, 0.80) | −0.28 (−0.53, 0.82) | −0.53 (−0.28, 0.90) | −0.18 (−0.79, 0.60) |
| [Δ] | 0.74 * (0.08, 0.95) | 0.72 * (0.02, 0.94) | 0.53 (−0.71, 0.71) | 0.52 (−0.29, 0.90) | 0.41 (−0.42, 086) |
* p < 0.05. Cmin = trough serum concentration; Cmax = peak serum concentration; t1/2 = half-life; Δ = change in serum concentration from trough to peak.