Database	Search Algorithm
OVID-Medline (PubMed) Up to January Week 3, 2021	#1. exp CRANIOCEREBRAL TRAUMA/ #2. exp Cerebrovascular Trauma/ #3. exp BRAIN EDEMA/ #4. ((brain or cerebral or intracranial) adj3 (oedema or edema or swell$)).ab,ti. #5. exp GLASGOW COMA SCALE/ #6. exp GLASGOW OUTCOME SCALE/ #7. exp UNCONSCIOUSNESS/ #8. (Glasgow adj3 (coma or outcome) adj3 (scale$ or score$)).ab,ti. #9. (Unconscious$ or coma$ or concuss$ or ‘persistent vegetative state’).ab,ti. #10. “Rancho Los Amigos Scale”.ab,ti. #11. ((head or crani$ or cerebr$ or capitis or brain$ or forebrain$ or skull$ or hemispher$ or intra-cran$ or inter-cran$) adj3 (injur$ or trauma$ or damag$ or wound$ or fracture$ or contusion$)).ab,ti. #12. “Diffuse axonal injur$”.ab,ti. #13. ((head or crani$ or cerebr$ or brain$ or intra-cran$ or inter-cran$) adj3 (haematoma$ or hematoma$ or haemorrhag$ or hemorrhag$ or bleed$ or pressure)).ab,ti. #14. or/#1–13 #15. randomized.ab,ti. #16. randomized controlled trial.pt. #17. controlled clinical trial.pt. #18. placebo.ab. #19. clinical trials as topic.sh. #20. randomly.ab. #21. trial.ti. #22. Comparative Study/ #23. #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 #24. (animals not (humans and animals)).sh. #25. #23 not #24 #26. #14 and #25 #27. Cytidine Diphosphate Choline/ #28. citicoline.ab,ti. #29. cdp-choline.ab,ti. #30. cytidine-5-diphosphocholine.ab,ti. #31. (“cdp choline” or cdpcholine).ab,ti. #32. #27 or #28 or #29 or #30 or #31 #33. #26 and #32
EMBASE Up to January Week 3, 2021	(‘acute brain injury’/exp OR ‘acute brain injury’ OR ‘brain injuries’/exp OR ‘brain injuries’ OR ‘brain injury’/exp OR ‘brain injury’ OR ‘brain injury, chronic’/exp OR ‘brain injury, chronic’ OR ‘cerebral injury’/exp OR ‘cerebral injury’ OR ‘cerebrum lesion’/exp OR ‘cerebrum lesion’ OR ‘chronic brain injury’/exp OR ‘chronic brain injury’ OR ‘injury, brain’/exp OR ‘injury, brain’ OR ‘left hemisphere injury’/exp OR ‘left hemisphere injury’ OR ‘right hemisphere injury’/exp OR ‘right hemisphere injury’ OR ‘brain injuries, traumatic’/exp OR ‘brain injuries, traumatic’ OR ‘brain lesion, traumatic’/exp OR ‘brain lesion, traumatic’ OR ‘brain system trauma’/exp OR ‘brain system trauma’ OR ‘brain trauma’/exp OR ‘brain trauma’ OR ‘cerebral trauma’/exp OR ‘cerebral trauma’ OR ‘cerebrovascular trauma’/exp OR ‘cerebrovascular trauma’ OR ‘encephalopathy, traumatic’/exp OR ‘encephalopathy, traumatic’ OR ‘mild traumatic brain injury’/exp OR ‘mild traumatic brain injury’ OR ‘organic cerebral trauma’/exp OR ‘organic cerebral trauma’ OR ‘posttraumatic encephalopathy’/exp OR ‘posttraumatic encephalopathy’ OR ‘traumatic brain injuries’/exp OR ‘traumatic brain injuries’ OR ‘traumatic brain injury’/exp OR ‘traumatic brain injury’ OR ‘traumatic brain lesion’/exp OR ‘traumatic brain lesion’ OR ‘traumatic cerebral lesion’/exp OR ‘traumatic cerebral lesion’ OR ‘traumatic encephalopathy’/exp OR ‘traumatic encephalopathy’ OR ‘brain edema’/exp OR ‘brain edema’ OR ‘brain oedema’/exp OR ‘brain oedema’ OR ‘cerebral edema’/exp OR ‘cerebral edema’ OR ‘cerebral oedema’/exp OR ‘cerebral oedema’ OR ‘edema, brain’/exp OR ‘edema, brain’ OR ‘oedema, brain’/exp OR ‘oedema, brain’ OR ‘cerebrocranial injury’/exp OR ‘cerebrocranial injury’ OR ‘cerebrocranial trauma’/exp OR ‘cerebrocranial trauma’ OR ‘closed head injuries’/exp OR ‘closed head injuries’ OR ‘cranial injury’/exp OR ‘cranial injury’ OR ‘cranial trauma’/exp OR ‘cranial trauma’ OR ‘craniocerebral injury’/exp OR ‘craniocerebral injury’ OR ‘craniocerebral lesion’/exp OR ‘craniocerebral lesion’ OR ‘craniocerebral trauma’/exp OR ‘craniocerebral trauma’ OR ‘craniocerebral wound’/exp OR ‘craniocerebral wound’ OR ‘head injuries’/exp OR ‘head injuries’ OR ‘head injuries, closed’/exp OR ‘head injuries, closed’ OR ‘head injuries, penetrating’/exp OR ‘head injuries, penetrating’ OR ‘head injury’/exp OR ‘head injury’ OR ‘head trauma’/exp OR ‘head trauma’ OR ‘head wound’/exp OR ‘head wound’ OR ‘injury, head’/exp OR ‘injury, head’ OR ‘penetrating head injuries’/exp OR ‘penetrating head injuries’ OR ‘trauma capitis’/exp OR ‘trauma capitis’ OR ‘trauma, cranial’/exp OR ‘trauma, cranial’ OR ‘trauma, head’/exp OR ‘trauma, head’) AND (‘cdp choline’/exp OR ‘cdp choline’ OR ‘brassel 1000’/exp OR ‘brassel 1000’ OR ‘ceraxon’/exp OR ‘ceraxon’ OR ‘cidifos’/exp OR ‘cidifos’ OR ‘cidiphos’/exp OR ‘cidiphos’ OR ‘citicholine’/exp OR ‘citicholine’ OR ‘citicolin’/exp OR ‘citicolin’ OR ‘citicolina’/exp OR ‘citicolina’ OR ‘citicoline’/exp OR ‘citicoline’ OR ‘cyticholine’/exp OR ‘cyticholine’ OR ‘cytidine 5 diphosphocholine’/exp OR ‘cytidine 5 diphosphocholine’ OR ‘cytidine 5‘ diphosphocholine’/exp OR ‘cytidine 5‘ diphosphocholine’ OR ‘cytidine 5‘ diphosphorylcholine’/exp OR ‘cytidine 5‘ diphosphorylcholine’ OR ‘cytidine diphosphate choline ester’/exp OR ‘cytidine diphosphate choline ester’ OR ‘cytidine diphosphocholine’/exp OR ‘cytidine diphosphocholine’ OR ‘cytocholine’/exp OR ‘cytocholine’ OR ‘nicholin’/exp OR ‘nicholin’ OR ‘rexort’/exp OR ‘rexort’ OR ‘sauran’/exp OR ‘sauran’ OR ‘sinkron’/exp OR ‘sinkron’ OR ‘sintoclar’/exp OR ‘sintoclar’ OR ‘somazina’/exp OR ‘somazina’ OR ‘cdp’/exp OR ‘cdp’ OR ‘cytidine 5‘ diphosphate’/exp OR ‘cytidine 5‘ diphosphate’ OR ‘cytidine diphosphate’/exp OR ‘cytidine diphosphate’ OR ‘cytosine diphosphate’/exp OR ‘cytosine diphosphate’ OR ‘cytidine diphosphate choline’/exp OR ‘cytidine diphosphate choline’) AND (‘clinical trial, controlled’/exp OR ‘clinical trial, controlled’ OR ‘controlled clinical comparison’/exp OR ‘controlled clinical comparison’ OR ‘controlled clinical drug trial’/exp OR ‘controlled clinical drug trial’ OR ‘controlled clinical experiment’/exp OR ‘controlled clinical experiment’ OR ‘controlled clinical study’/exp OR ‘controlled clinical study’ OR ‘controlled clinical test’/exp OR ‘controlled clinical test’ OR ‘controlled clinical trial’/exp OR ‘controlled clinical trial’ OR ‘review, systematic’/exp OR ‘review, systematic’ OR ‘systematic review’/exp OR ‘systematic review’ OR ‘meta analysis’/exp OR ‘meta analysis’)