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Cu impairs CREB/BDNF signaling of mice hippocampal. (A) Effects of Cu on the proteins expression of TrkB, PSD-95, pCREB, CREB, SYP, BDNF and Bax, Bcl-2 in mice hippocampus. (B) Quantitative analysis of TrkB, PSD-95, pCREB/CREB, SYP, BDNF and Bax/Bcl-2. (C–E) Serotonin (5-HT), dopamine (DA), and γ-aminobutyric acid (GABA) levels in the brain of the mice. * p < 0.05, ** p < 0.01, *** p < 0.001.
