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Legend. Neutrophils are pleiotropic cells that play a central role in the very early phase of SpA development, contributing to triggering inflammation in multiple tissues. Neutrophils are recruited from the bloodstream to target sites in Spondyloarthritis (SpA), such as joints, entheses, gut, skin, and eyes, where they produce neutrophils extracellular traps (NETs), cytokines, and chemokines to attract and activate other immune cells, boosting type 3 immunity.
