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. 2023 Feb 7;24(4):3308. doi: 10.3390/ijms24043308

Figure 3.

Figure 3

siRNA-mediated knockdown of NumbL inhibited GLT-induced apoptosis of Ins1 832/13 cells. (A) Cleaved caspase-3 activity after exposure of cells to GLT for the indicated time periods. (B) Representative blot and quantification of NumbL protein levels from cells treated with a control RNAi (siControl) or RNAi to NumbL (siNumbL). * p < 0.05 (t-test). (C) Representative blot and quantification of cleaved caspase-3 protein from cells treated with siNumbL either under NG or GLT for 12 h. * p < 0.05 vs. siControl treated under NG; # p < 0.05 vs. siControl treated under GLT (ANOVA). (D) Cleaved caspase-3 activity in siRNA-treated cells after culturing in NG and GLT conditions for 12 h. * p < 0.05 vs. siControl treated with NG; # p < 0.05 vs. siControl treated with GLT. The data are representative from at least three independent experiments.