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. 2023 Feb 7;24(4):3308. doi: 10.3390/ijms24043308

Figure 4.

Figure 4

NumbL downregulation prevented GLT-mediated activation of NF-κB signaling. (A,B) Representative histogram and immunoblot of IkBa protein using the capillary Western blot system from human islets treated with GLT conditions for the indicated time periods. (C) Quantification of IkBa protein. The quantification data are from three independent experiments. * p < 0.05 vs. ‘0 h GLT’ group. (D,E) Representative immunoblot and quantification of IkBa protein from siRNA-treated 832/13 Ins1 cells cultured in NG or GLT conditions for 12 h. * p < 0.05 vs. siControl group under NG. (F,G) Representative immunoblot and quantification of phospho-p65 protein from siRNA-treated 832/13 Ins1 cells cultured in NG or GLT conditions for 12 h. * p < 0.05 vs. siControl group under NG; # p < 0.05 vs. siControl group under GLT. The data are representative from at least three independent experiments.