AKT/PKB |
serine/threonine kinase/protein kinase B |
AMBRA1 |
Autophagy and beclin 1 regulator 1 |
AMPK |
5′ Adenosine-monophosphate-activated protein kinase |
APC |
Adenomatous polyposis coli |
ATG |
Autophagy-related genes or proteins |
BAX |
Bcl-2-associated X protein |
BECN1 |
Beclin1, a mammalian ortholog of the yeast Atg6
|
BEST4 |
Bestrophin 4 |
BNIP3 |
Bcl-2-interacting protein 3 |
BNIP3L |
Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3-like |
BRAF |
Proto-oncogene B-Raf; encodes protein called B-Raf |
CCL2/MCP-1 |
Chemokine (C-C Motif) ligand 2/monocyte chemoattractant protein 1 |
CCL8/MCP-2 |
Chemokine (C-C Motif) ligand 8/monocyte chemoattractant protein 2 |
C/E/I/M(SCs) |
Cancer/embryonic/intestinal/mesenchymal stem cells |
CD |
Crohn’s disease |
CI |
Confidence interval |
CIMP |
CpG island methylator phenotype |
CIN |
Chromosomal instability |
c-MET |
Tyrosine-protein kinase Met/hepatocyte growth factor receptor (HGFR) |
c-Myc |
Proto-oncogene protein; transcription factor |
CQ |
Chloroquine |
CRC |
Colorectal cancer |
CSCs |
Cancer stem cells |
c-Src |
Src proto-oncogene, non-receptor tyrosine kinase |
DECP1 |
Double FYVE-containing protein 1 or ZFYVE1 protein |
EGF/EGFR |
Epidermal growth factor/EGF receptor (HER1 in humans) |
eIF4A3 |
Eukaryotic initiation factor 4A-III |
ERK1/2 |
Extracellular signal-regulated kinase 1/2 |
FAK |
Focal adhesion kinase or protein tyrosine kinase 2 |
FOXO |
Forkhead box protein class O |
GAPs |
Goblet cell-associated antigen passage |
GH/GH-R |
Growth hormone/GH-receptor |
GLP-2 |
Glucagon-like peptide 2 |
GNPTAB |
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta |
GSK-3β |
Glycogen synthase kinase-3β |
HIF-1 |
Hypoxia-inducible factor 1 |
IBD |
Inflammatory bowel diseases |
IECs |
Intestinal epithelial cells |
IGF-1, -2 |
Insulin growth factor 1, -2 |
IGF-1R, -2R |
IGF receptor type I, type II |
IGF-BPs |
IGF-binding proteins |
IR-A |
Isoform A of the insulin receptor |
IRS-1/2 |
Insulin receptor substrate 1/2 |
JAK |
Janus kinase |
KLF4 |
Gut-enriched Kruppel-like factor 4; zinc-finger transcription factor |
KRAS |
Kirsten rat sarcoma virus; encodes protein called K-Ras |
LAMP2 |
Lysosome-associated membrane protein 2 |
(M)LC3B/MAP2 |
Microtubule-associated protein 1A/1B light chain 3B/protein 2 |
LKB1 |
Liver kinase B1; serine/threonine protein kinase (STK11) |
lncRNAs |
Long non-coding RNAs |
LOI |
Loss of imprinting |
MAPK |
Mitogen-activated protein kinase |
MEFs |
Mouse embryonic fibroblasts |
MEK1/2 |
Mitogen-activated protein kinase (MAP2K, MEK, MAPKK) |
MetS |
Metabolic syndrome |
MOI |
Maintenance of imprinting |
MSI-H |
High microsatellite instability |
MSS |
Microsatellite stable |
mTORC1/2 |
Mammalian target of rapamycin complex 1/complex 2 |
NADPH |
Nicotinamide adenine dinucleotide phosphate oxidase |
NANOG |
Homebox protein, transcription factor |
NF-κB |
Nuclear factor-kappa B |
NRF-1/2 |
Nuclear respiratory factor 1/2 |
OCT-4 |
Octamer-binding transcription factor 4 |
OS |
Overall survival |
PARP1 |
Poly [ADP-ribose] polymerase 1 |
PGDF |
Platelet-derived growth factor |
PI3K |
Phosphatidylinositol-3-kinase |
PIK3CA |
Gene encoding phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
PINK1 |
PTEN-induced kinase 1 |
PLCs |
Paneth-like cells |
PKCα/PRKCA |
Protein kinase Cα |
PPAR |
Peroxisome proliferator-activated receptor |
PSCs |
Pluripotent stem cells |
PTEN |
Phosphatase and tensin homolog deleted on chromosome ten |
Raf-1 |
Proto-oncogene serine/threonine protein kinase |
Raptor |
Regulatory-associated protein of mTOR |
RAS |
Oncogene “Rat sarcoma virus” from three Ras genes: HRAS, KRAS and NRAS |
ROS |
Reactive oxygen species |
SATB2 |
SATB homeobox 2; DNA-binding protein |
SGK-1 |
Serine/threonine-protein kinase/serum and glucocorticoid-regulated kinase 1 |
SHC |
SHC-transforming protein 1 encoded by the SHC gene |
SIRT1 |
NAD-dependent deacetylase sirtuin 1, a mammalian homologue of silent information regulator 2 of the yeast Saccharomyces cerevisiae
|
SLITs/ROBOs |
SLIT glycoproteins and their roundabout receptors |
SNP |
Single nucleotide polymorphism |
SNX9, -18,-33 |
Sorting nexin9, -18, -33 |
SOD3 |
Superoxide dismutase 3 |
SOX2 |
Transcription factor 2, known also as sex-determining region Y (SRY)-box 2 |
STAT3 |
Signal transducer and activator of transcription 3 |
TCGA |
The cancer genome atlas |
TGF-α, β |
Tumor growth factor α, β |
TLRs |
Toll-like receptors |
TME |
Tumor microenvironment |
TP53 |
Tumor gene/protein 53 |
UC |
Ulcerative colitis |
ULK1/2 |
Unc-51 like autophagy activating kinase |
uPA/uPAR |
Urokinase-type plasminogen activator/receptor |
Wnt |
Gene wingless + integrated or int-1
|