Skip to main content
. 2023 Feb 11;24(4):3665. doi: 10.3390/ijms24043665
AKT/PKB serine/threonine kinase/protein kinase B
AMBRA1 Autophagy and beclin 1 regulator 1
AMPK 5′ Adenosine-monophosphate-activated protein kinase
APC Adenomatous polyposis coli
ATG Autophagy-related genes or proteins
BAX Bcl-2-associated X protein
BECN1 Beclin1, a mammalian ortholog of the yeast Atg6
BEST4 Bestrophin 4
BNIP3 Bcl-2-interacting protein 3
BNIP3L Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3-like
BRAF Proto-oncogene B-Raf; encodes protein called B-Raf
CCL2/MCP-1 Chemokine (C-C Motif) ligand 2/monocyte chemoattractant protein 1
CCL8/MCP-2 Chemokine (C-C Motif) ligand 8/monocyte chemoattractant protein 2
C/E/I/M(SCs) Cancer/embryonic/intestinal/mesenchymal stem cells
CD Crohn’s disease
CI Confidence interval
CIMP CpG island methylator phenotype
CIN Chromosomal instability
c-MET Tyrosine-protein kinase Met/hepatocyte growth factor receptor (HGFR)
c-Myc Proto-oncogene protein; transcription factor
CQ Chloroquine
CRC Colorectal cancer
CSCs Cancer stem cells
c-Src Src proto-oncogene, non-receptor tyrosine kinase
DECP1 Double FYVE-containing protein 1 or ZFYVE1 protein
EGF/EGFR Epidermal growth factor/EGF receptor (HER1 in humans)
eIF4A3 Eukaryotic initiation factor 4A-III
ERK1/2 Extracellular signal-regulated kinase 1/2
FAK Focal adhesion kinase or protein tyrosine kinase 2
FOXO Forkhead box protein class O
GAPs Goblet cell-associated antigen passage
GH/GH-R Growth hormone/GH-receptor
GLP-2 Glucagon-like peptide 2
GNPTAB N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
GSK-3β Glycogen synthase kinase-3β
HIF-1 Hypoxia-inducible factor 1
IBD Inflammatory bowel diseases
IECs Intestinal epithelial cells
IGF-1, -2 Insulin growth factor 1, -2
IGF-1R, -2R IGF receptor type I, type II
IGF-BPs IGF-binding proteins
IR-A Isoform A of the insulin receptor
IRS-1/2 Insulin receptor substrate 1/2
JAK Janus kinase
KLF4 Gut-enriched Kruppel-like factor 4; zinc-finger transcription factor
KRAS Kirsten rat sarcoma virus; encodes protein called K-Ras
LAMP2 Lysosome-associated membrane protein 2
(M)LC3B/MAP2 Microtubule-associated protein 1A/1B light chain 3B/protein 2
LKB1 Liver kinase B1; serine/threonine protein kinase (STK11)
lncRNAs Long non-coding RNAs
LOI Loss of imprinting
MAPK Mitogen-activated protein kinase
MEFs Mouse embryonic fibroblasts
MEK1/2 Mitogen-activated protein kinase (MAP2K, MEK, MAPKK)
MetS Metabolic syndrome
MOI Maintenance of imprinting
MSI-H High microsatellite instability
MSS Microsatellite stable
mTORC1/2 Mammalian target of rapamycin complex 1/complex 2
NADPH Nicotinamide adenine dinucleotide phosphate oxidase
NANOG Homebox protein, transcription factor
NF-κB Nuclear factor-kappa B
NRF-1/2 Nuclear respiratory factor 1/2
OCT-4 Octamer-binding transcription factor 4
OS Overall survival
PARP1 Poly [ADP-ribose] polymerase 1
PGDF Platelet-derived growth factor
PI3K Phosphatidylinositol-3-kinase
PIK3CA Gene encoding phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PINK1 PTEN-induced kinase 1
PLCs Paneth-like cells
PKCα/PRKCA Protein kinase Cα
PPAR Peroxisome proliferator-activated receptor
PSCs Pluripotent stem cells
PTEN Phosphatase and tensin homolog deleted on chromosome ten
Raf-1 Proto-oncogene serine/threonine protein kinase
Raptor Regulatory-associated protein of mTOR
RAS Oncogene “Rat sarcoma virus” from three Ras genes: HRAS, KRAS and NRAS
ROS Reactive oxygen species
SATB2 SATB homeobox 2; DNA-binding protein
SGK-1 Serine/threonine-protein kinase/serum and glucocorticoid-regulated kinase 1
SHC SHC-transforming protein 1 encoded by the SHC gene
SIRT1 NAD-dependent deacetylase sirtuin 1, a mammalian homologue of silent information regulator 2 of the yeast Saccharomyces cerevisiae
SLITs/ROBOs SLIT glycoproteins and their roundabout receptors
SNP Single nucleotide polymorphism
SNX9, -18,-33 Sorting nexin9, -18, -33
SOD3 Superoxide dismutase 3
SOX2 Transcription factor 2, known also as sex-determining region Y (SRY)-box 2
STAT3 Signal transducer and activator of transcription 3
TCGA The cancer genome atlas
TGF-α, β Tumor growth factor α, β
TLRs Toll-like receptors
TME Tumor microenvironment
TP53 Tumor gene/protein 53
UC Ulcerative colitis
ULK1/2 Unc-51 like autophagy activating kinase
uPA/uPAR Urokinase-type plasminogen activator/receptor
Wnt Gene wingless + integrated or int-1