Table 1.
Inhibition of SARS-CoV-2 Mpro by natural and synthesized compounds.
| Chemical Structure | SARS-CoV-2 Mpro | |
|---|---|---|
| % Inhibition at 10 μM |
IC50 (μM) | |
 (+)-Nootkaton |
32.04 | >10 |
 Costunolide |
27.96 | >10 |
 Alantolacton |
27.55 | >10 |
 (−)-Parthenolide |
20.06 | >10 |
 (−)-α-Santonin |
24.13 | >10 |
 Dehydrocostus lactone |
13.39 | >10 |
 Oridonin |
81.87 | 4.67 |
 Osthole |
4.98 | >10 |
 Tanshinone I |
7.03 | >10 |
 Sinomenine |
4.80 | >10 |
 Resibufogenin |
6.32 | >10 |
 Cinobufagin |
0.53 | >10 |
 α-Mangostin |
38.56 | 25.12 |
 Gambogic acid |
22.75 | >10 |
 Loganin |
29.43 | >10 |
 l-Ascorbic acid |
22.25 | >10 |
 Fisetin |
−11.21 | >10 |
 Robinetin |
86.13 | 0.96 |
 Myricetin |
104.00 | 0.645 |
 Tricetin |
72.28 | 7.84 |
 Luteoline |
9.65 | >10 |
 Scutellarein |
76.07 | 6.07 |
 Myricitrin |
11.67 | >10 |
 Quercitrin |
2.42 | >10 |
 l-Epigallocatechin gallate |
105.40 | 0.228 |
 Piceatannol |
76.90 | 2.031 |
 Resveratrol |
5.96 | >10 |
 Rosmarinic acid |
50.56 | 6.84 |
 Salvianolic acid A |
50.84 | 28.38 |
 Orlistat |
20.99 | >10 |
 3-O-Ethyl-l-ascorbic acid |
24.94 | >10 |