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. 2023 Jan 18;15(2):320. doi: 10.3390/pharmaceutics15020320

Figure 2.

Figure 2

Chemical structure of several linker molecules connecting solid supports and lipids used for the preparation of lipid-oligonucleotide conjugates. (A) Lipid conjugation to the 5′ or 3′ end of an oligonucleotide in solution [35,36,37]. (B) Lipid conjugation to the 5′ or 3′ terminus of an oligonucleotide on a solid support [29,31].