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. 2023 Jan 18;15(2):320. doi: 10.3390/pharmaceutics15020320

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Postsynthetic reactions for the synthesis of oligonucleotide-peptide conjugates. (A) Using protected peptide segments for fragment condensation [175], (B) thiol-maleimido and thiol-bromoacetamido reactions [176], (C) disulfide formation [177,178,179], (D) synthesis by native ligation [180], (E) oximes or thiozolidine reactions [181,182,183], (F) conjugation by Diels-Alder reaction [184,185], (G) conjugation reactions catalyzed by copper to produce alkyne-azide cyclo additions [186,187,188].