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. 2023 Jan 18;15(2):320. doi: 10.3390/pharmaceutics15020320

Figure 8.

Figure 8

Schemes of DNA nanostructures carrying multifunctional ligands to improve drug delivery. (A) G-quadruplex functionalized with ASOs and hydrophobic groups [202,203], (B) G-quadruplex functionalized with FdUn oligomers [204], (C) DNA tetrahedron with four siRNAs carrying folic acid [205], (D) DNA tetrahedron and DNA origami functionalized with cholesterol moieties to deliver floxuridine [206], and (E) DNA cube with oligonucleotides carrying dendritic alkyl chains being able to modulate the affinity to human serum albumin [207].