Table 3.
Variables | Univariate Analysis | Multivariate Analysis | |||
---|---|---|---|---|---|
HR (95% CI) | p-Value | HR (95% CI) | p-Value | ||
Age > 75 yrs | 2.50 (1.96–3.18) | <0.0001 | 2.14 (1.60–2.87) | <0.0001 | |
Men | 0.83 (0.65–1.06) | 0.134 | 0.99 (0.72–1.34) | 0.928 | |
Tobacco use | 0.70 (0.55–0.88) | 0.002 | 0.89 (0.66–1.20) | 0.447 | |
Overt diabetes mellitus | 0.90 (0.72–1.14) | 0.395 | - | - | |
Hyperlipemia: | no | Ref. | Ref. | Ref. | Ref. |
under therapy | 0.64 (0.51–0.81) | <0.0001 | 0.69 (0.51–0.93) | 0.015 | |
no therapy | 0.86 (0.50–1.50) | 0.602 | 0.97 (0.51–1.86) | 0.937 | |
Arterial hypertension | 1.04 (0.69–1.55) | 0.865 | - | - | |
Chronic renal insufficiency: | 1.92 (1.52–2.43) | <.0001 | 1.54 (1.28–1.84) | <0.0001 | |
no | Ref. | Ref. | Ref. | Ref. | |
creatinine > 2 | 1.42 (1.06–1.92) | 0.021 | 0.84 (0.59–1.21) | 0.354 | |
hemodialysis treatment | 2.89 (2.15–3.88) | <0.0001 | - | - | |
Coronary artery disease: | 1.51 (1.20–1.90) | <0.0001 | 1.26 (1.02–1.57) | 0.036 | |
no | Ref. | Ref. | Ref. | Ref. | |
revascularized | 1.47 (1.14–1.89) | 0.003 | 1.20 (0.88–1.65) | 0.255 | |
non-revascularized | 1.64 (1.16–2.32) | 0.005 | - | - | |
Chronic obstructive pulmonary disease | 1.02 (0.80–1.29) | 0.902 | - | - | |
Cerebrovascular disease: | 1.48 (1.01–2.17) | 0.046 | - | - | |
No | Ref. | Ref. | Ref. | Ref. | |
previous TIA | 1.86 (1.25–2.76) | 0.002 | 1.53 (0.95–2.46) | 0.084 | |
previous stroke | 0.39 (0.10–1.57) | 0.19 | 0.38 (0.1–1.55) | 0.177 | |
Necrosis/infection of the foot: | no | Ref. | Ref. | Ref. | Ref. |
dry | 1.83 (1.35–2.48) | <0.0001 | 1.42 (1.02–1.98) | 0.040 | |
wet | 3.15 (2.39–4.13) | <0.0001 | 2.04 (1.46–2.85) | <0.0001 | |
First intervention: | endovascular only (rarely, regenerative cellular therapy) | Ref. | Ref. | Ref. | Ref. |
any open revascularization | 0.81 (0.62–1.06) | 0.122 | 0.86 (0.64–1.15) | 0.310 | |
any major amputation | 3.05 (2.25–4.13) | <0.0001 | - | - | |
Any intervention below the knee | 1.06 (0.84–1.33) | 0.624 | - | - | |
Associated minor amputation | 1.29 (0.96–1.73) | 0.091 | - | - | |
Technical success of CLTI revascularization | 0.83 (0.55–1.25) | 0.37 | - | - | |
Postoperative antiplatelets, anticoagulants, statins: | monotherapy | Ref. | Ref. | Ref. | Ref. |
two medications | 0.63 (0.48–0.82) | 0.001 | 0.93 (0.67–1.29) | 0.678 | |
three or more medications | 0.52 (0.37–0.73) | <0.0001 | 0.78 (0.52–1.18) | 0.243 | |
Clinical success of CLTI revascularization: | worsen | Ref. | Ref. | Ref. | Ref. |
no change | 0.81 (0.50–1.34) | 0.415 | 1.02 (0.59–1.77) | 0.949 | |
improved | 0.58 (0.38–0.88) | 0.011 | 0.89 (0.52–1.51) | 0.666 | |
Limb salvage | 0.41 (0.32–0.52) | <0.0001 | 0.71 (0.47–1.06) | 0.095 |
TIA, transient ischemic attack. CLTI, chronic limb-threatening ischemia.