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. 2023 Feb 4;24(4):3086. doi: 10.3390/ijms24043086

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

IMC shows the structural and cellular iTME constitutions in the cutaneous squamous cell carcinomas (cSCC), representing lymphatic vessels (podoplanin), blood vessels and cancer-associated fibroblasts (αSMA), nerve fibers (pan-neurofilament), tumor cells (pan-cytokeratin), extracellular matrix (fibronectin) and immune cells (CD45), nuclei, and hematoxylin-eosin-saffron (HES) also were done in the same region. Scale bar 100 µm. (Reprinted with permission from [75]. Copyright 2021 Frontiers Media SA).