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. 2023 Feb 6;24(4):3170. doi: 10.3390/ijms24043170

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HPLC profiles of permethrin and substrate metabolism mediated by the expressed P450/CPR isomers. Reactions were performed with 20 µM chemical (cis-/trans-permethrin, PBalc or PBald), 1 mM NADPH, 0.25 mM MgCl₂ and 0.2 μM P450s/CPR microsomal proteins incubated for 2 h at 30 °C. Each P450/CPR protein with NADPH had a control reaction consisting of the same microsome without NADPH. A negative control with Sf9 cell microsomes (0.2 μM) and without P450/CPR expression was used to calculate substrate depletion. (A) Percentage of trans-permethrin depletion. (B) Percentage of cis-permethrin depletion. (C) Percentage of PBalc depletion. (D) Percentage of PBald depletion. Data shown as mean ± S.E.M (n = 3).