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. 2023 Feb 8;24(4):3391. doi: 10.3390/ijms24043391

Figure 1.

Figure 1

Janus kinase-signal transducer and activator of transcription pathway. Cytokines bind to their receptor, leading to the activation of Jak and their phosphorylation. Subsequently, STAT is phosphorylated and dimerized. Activated STAT dimers translocate to the nucleus and regulate gene transcription and expression. Created with BioRender.com (accessed on 14 January 2023). Abbreviations: FERM, 4.1 ezrin, radixin moesin domain; SH2, Src-homology 2 domain; JH1, jak homology domain 1 (kinase domain); JH2, jak homology domain 2 (pseudokinase domain).