Table 1.

Experimental matrix of randomized runs in Box–Behnken design.

Formulation Code	X1 Shaking Speed (rpm)	X2 Shaking Time (min)	X3 HON Concentration (mg/mL)
F1	200	15	2
F2	400	15	2
F3	200	195	2
F4	400	195	2
F5	200	105	1
F6	400	105	1
F7	200	105	3
F8	400	105	3
F9	300	15	1
F10	300	195	1
F11	300	15	3
F12	300	195	3
F13	300	105	2
F14	300	105	2
F15	300	105	2