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. 2023 Feb 13;24(4):3747. doi: 10.3390/ijms24043747

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Enrichment analysis of biological processes related to genes regulated by OHT in combination with ATRA. Statistically significantly enriched biological processes based on Gene Ontology enrichment analysis, with the number of corresponding genes, upon treatment of MCF7-WT (A) MCF7-ERβ1 (B) and MCF7-ERβ2 cells (C) with OHT in combination with ATRA. The number of significantly differentially expressed genes involved in each process is shown on the X axis, with red and blue colors corresponding to up- or downregulation, respectively. Cell-death-related processes are indicated with dots. OHT, 4-hydroxytamoxifen; ATRA, all-trans retinoic acid.