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The protease inhibitors block SARS-CoV-2 replication in human PCLS of two different donors. (A) Scheme of the experimental setup. (B,C) Human PCLS were incubated with 30 µM of selected protease inhibitors and infected with SARS-CoV-2. All infections were performed in triplicates. Viral infectivity was determined by infecting Vero cells in duplicates with the supernatants. Viral loads were determined by RT-qPCR.
