Table 1.

Inhibition of SARS-CoV-2 dependent on the infected cell line.

Compound Class	Compound	Antiviral Activity a,b			EC50 c [µM]
		Vero	Huh-7	Calu-3
Disulfiram		1.5 ± 0.7	2.0 ± 0.4	0.2 ± 0.1
Pyridin-3-yl 1H-indole-2-carboxylates and analogs	1	0.6 ± 0.2	0.8 ± 0.2	n.a.
	2	1.6 ± 0.4	2.8 ± 1.3	tox
	3	0.2 ± 0.2	2.0 ± 0.2	1.1 ± 0.4
	4 d	0.1 ± 0.1	0.5 ± 0.3	n.a.
	5 d	0.1 ± 0.1	0.0	0.0
Pyridin-3-yl-1H-indole-4-, 5-, or 7-carboxylates and analogs	6	3.2 ± 0.6	4.2 ± 0.0	1.0 ± 0.7	5.8
	7	2.8 ± 1.0	5.3 ± 0.1	1.2 ± 0.3	9.9
	8	0.6 ± 0.3	2.4 ± 0.1	2.0 ± 0.6
	9	3.8 ± 0.3	3.6 ± 0.5	1.7 ± 0.7
	10 e	0.0	0.3	n.a.
Azapeptide nitriles	11	3.3 ± 1.4	3.2 ± 0.8	0.0
	12	4.6 ± 0.2	tox	2.4 ± 1.0
	13	n.a.	tox	tox
	14	n.a.	tox	tox
	15	0.0	0.5 ± 0.1	0.0
	16	4.1 ± 0.7	1.0 ± 0.1	n.a.	2.4
	17	0.0	0.0	0.0
	18	0.0	1.6 ± 0.6	0.1
	19	0.0	0.0	0.3
	20	0.0	0.8	0.1

^a Reduction in logarithmic scale compared to the control. Depicted is the mean from at least three independent experiments performed in triplicate assays. Tox: substance showed toxicity; n.a.: not analysed. ^b Compounds were tested at a concentration of 30 µM. ^c The EC₅₀ was determined on Vero cells. ^d Benzo[b]thiophene and benzofuran derivatives, respectively. ^e 2,3,4,9-Tetrahydro-1H-carbazole derivative.