Table 1.

Examples of radiosensitizer drugs that enhance the lethal effects of radiation and have anticancer properties.

Drug Class	Drug	Anticancer Mechanism	References
Antidyslipidemic drugs	Statins	HMG-CoA reductase inhibitor; block mevalonate pathway	[2,5,10]
Anti-inflammatory drugs	Diclofenac	COX inhibitor; prostaglandin inhibitor; MYC inhibitor; regulates glucose metabolism	[2]
Antiviral drugs	Nelfinavir	S2P activity inhibitor; inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1; Akt inhibitor; blocks androgen receptor signaling; down-regulates the androgen receptor	[2,5,15]
	Saquinavir	Inhibition of the 20s and 26s proteasome; NF-κB inactivator; PI3K-Akt inhibitor	[16]
Antiparasitic drugs	Chloroquine/Hydroxychloroquine	Interaction with nucleotides; apoptosis induction; autophagy inhibitor; elimination of cancer stem cells	[5,17]
Other drugs	Naftopidil	Akt phosphorylation inhibitor	[2,5]